The present work describes development for colon targeted drug delivery by combination approach i.e., a polysaccharide based system and pH based matrix systems for colonic delivery of naproxen for inflammatory bowel diseases. Matrix core tablets were prepared by using polysaccharides like guar gum, Chitosan and sodium alginate alone and its combinations. Drug release studies were performed in gastric pH (1.2) for first 2hr and in pH 6.8 for next 3 hrs and finally at pH 7.4 for up to 24 hrs. The Naproxen uncoated or core tablets shows maximum amount of drug release in pH 1.2 and pH 6.8 so in order to mimic the drug release in upper GIT enteric coating was done for optimized formulation . Formulation F1, F4 and F13 were selected for enteric coating with Eudragit S-100. The enteric coated formulations shows negligible amount of drug releases in the stomach and maximum amount of drug release in colonic environment. Among all formulations F13 had shown good drug release in colonic environment. Further physiochemical characterization, pre and post compression were also conducted, all the results obtained are in acceptable limit.

Digoxin belongs to a class of medications called cardiac glycosides. It works by affecting certain minerals (sodium
and potassium) inside heart cells. This reduces strain on the heart and helps it maintain a normal, steady, and strong heartbeat.
It is also used to treat certain types of irregular heartbeat (such as chronic atrial fibrillation). This UV-spectrophotometric
technique is quite simple, accurate, precise, reproducible, and sensitive. The UV method has been developed for quantification
of digoxin in tablet formulation. The validation procedure confirms that this is an appropriate method for their quantification
in the formulation. It is also used in routine quality control of the formulations containing this entire compound.