Modern analytical techniques are playing key role in assessing chemical quality standards of medicine. This analytical techniques are required for fixing standards of medicines and its regular checking. Out of all analytical techniques, the technique which is widely used to check the quality of drug is known as chromatography. UV/Vis spectrophotometers, including diode array detectors, are the most commonly employed detectors. These detectors acquire absorbance data over the entire UV-visible range, thus providing the analyst with chromatograms at multiple, selectable wavelengths, spectra of the eluting peaks and also peak purity

The aim of the current study was Determination of High Performance Thin Layer Chromatography and High-Performance Liquid Chromatography Method of Aceclofenac in Emulgel. The topical delivery system is generally used when other drugs cannot be administered or when local skin infections such as fungi are present. Local dermatological disorders can be effectively treated with drug delivery to the skin. The skin protects the body from invading pathogens with its formidable barrier functions. formulation of Aceclofenac containing emulgel were prepared and this prepared formulation was analysed as per the official guidelines. There is no doubt that aceclofenac emulgels will be the most commonly procured dosage form in the future due to their better therapeutic potential and fewer adverse effects on patients

The skin is a very attractive organ for the application of pharmaceutically active substances due to its considerable size and easy accessibility. The aim of the drug administration via the skin can be either the local therapy of dermatological diseases or the transdermal delivery of drugs to the underlying tissues or the systemic circulation. Although much work has been done to improve the appearance of the patches some are still criticized by patients for their high visibility and the resulting lack of discreetness. An example for a highly visible finally it has to be pointed out that the production of polymeric patches requires specialized production equipment and generates considerable manufacturing costs

Rheumatic arthiritis is an autoimmune and inflammatory disease, which means that immune system attacks healthy cells by causing inflammation in the affected parts of the body. The plant Nephrolepis cordifolia belonging to the family Nephrolepidaceae has traditional claim for Anti - rheumatic activity. Evaluation of crude drug can be attempted by different method which includes morphological and microscopical studies of the crude by analyzing the chemical, physical and biological behaviour. Shade dried powdered plant material of leaves of Nephrolepis cordifolia was used for the determination of physio chemical constants in accordance with WHO guidelines. Phytochemical evaluation is used to determine the nature of phyto-constituents present in the plant by using suitable chemical tests.The anatomical examination of Nephrolepis cordifolia leaf exhibited important microscopical characters such as xylem, phloem, palisade parenchyma, spongy parenchyma. Powder microscopy revealed the presence of sclereids, Epidermal cells. In phytochemical Screening, successive solvent extraction was carried out with ethanol, chloroform and hexane as solvent. Ethanol extract leaves showed maximum yield of 5.25% W/W. Efficacy of the extract was screened by evaluating anti rheumatic activity. FT-IR spectra had amply evidenced the occurrence of OH group. The FT-IR spectrum showed the presence of an alkyl amine, phenol ring, cycloalkane and carbonyl compounds. The results confirm the fact that this plant possess important bioactive constituent, hence to ensure the anti rheumatoid activity further scientific investigation will be proposed.

Pharmacists examined the effectiveness of bioidentical hormones (BH) for treating menopausal symptoms. Statistical analysis was performed using descriptive statistics. Approximately 650 e-mails were sent to pharmacists, and 55 responded (response rate 4.35%). BHs are not immune to adverse drug reactions (93%) according to the majority of respondents. Medroxyprogesterone acetate and Conjugated equine oestrogens are not examples of BHs, according to more than 50% of respondnent. 35-45% percent of respondents said they didn't know the answers to seven of eleven knowledge questions. Many respondents believed that BHs were similar in efficacy to conventional hormone therapy or better than CHT for vasomotor symptoms or equally effective BHs and CHT were rated as equally safe by the majority of respondents. Respondents also suggested that more educational sessions were needed, particularly in regard to the safety and efficacy of BHTs over CHTs. Pharmacy professionals knew that BHs had adverse effects, but did not possess knowledge in other areas. Literature and curriculum for pharmacy schools, this topic may receive little attention. Programs in pharmacy for undergraduates are being modified and supplemental CPE could be used to educate pharmacists about BHs

This study evaluated diabetes patients' self-monitoring of blood glucose using a quality assurance process at a community pharmacy, investigated whether the quality of self-monitoring of blood glucose improved after the procedure was implemented, and examined the patient opinions. The results of patient blood glucose measurements were compared to the results obtained with HemoCue Glucose 201 by pharmacy employees in 16 community pharmacies. A checklist of eight items was used to monitor patient performance. When blood glucose measurements differed by more than 20% from pharmacy measurements, the patient was instructed about using the glucometer correctly. A second measurement of blood glucose was then taken by the patients. Glucometer strips and a new glucometer were substituted if the results were still out of the set limits after the control procedure. Upon returning three months later, the patients had a follow-up visit. The first visit found that 5% of the 169 patients had measurements deviating by more than 20% from pharmacy blood glucose values, and 50% of patients were experiencing use errors. On the second visit, there was no significant difference in patient measurements' analytical quality, but there was a decrease in patient errors to 29 percent (p 0.001). In 81% of the cases, patients adjusted medication, exercise, or meals based on blood glucose results. 51% of the patients said their measurements were more reliable after a second visit. Approximately 80% of patients requested annual assessments of their measurements. In this survey, 83% of patients preferred a pharmacy assessment. The number of errors in self-monitoring blood glucose by patients was significantly reduced by a quality assessment procedure developed by the community pharmacy. The clinical measurements of the patients were of good analytical quality and did not improve further during the study. A selection bias of participating patients might explain the high analytical quality. After reviewing their measurements at the pharmacy, patients reported a higher level of confidence in their blood glucose measurements

Several pharmaceuticals are lipophilic today, and many of them are soluble in water only in small amounts, especially antidiabetic pharmaceuticals like Nateglinide. As a result of the low water solubility of this medicine, its bioavailability and effectiveness are significantly reduced. A new class of oral hypoglycemic drugs is being developed to control blood glucose fluctuations following meals. Even though it doesn't work like sulfonylureas, a lot of metabolic processing occurs during its first passage through the body, limiting its bioavailability. Drug particles are dispersed in colloidal dispersion with surfactants to make nanosuspensions. Low soluble and high permeable chemicals present significant challenges to formulators. In our study, we examined the spectra of medication, pure polymers, and nanosuspension formulations for their biological properties. There was no significant interaction between the medication and polymer. In vitro drug release, penetration efficiency, amount of drug, surface morphology, and yield were examined in the formulations. It was found that drugs are distinctive, round, and smooth in nanosuspensions. A very rapid release of Nateglinide was observed in vitro, followed by a very slow release of the drug during a later period of time. When the nanoparticle is first released, some of the drug remains on the surface of the nanoparticle in a rapid first release situation. When compared to other formulations, NNF4 is found to have the best performance regarding the release of a drug than those other formulations. There is a clear preference for Peppa's and Higuchi's models regarding drug release, while R2 values tend to indicate a greater release rate in all formulations. We found the 'n' value to be less than 0.50 for all formulations. This indicates a Fickian diffusion mechanism is likely to be involved