1. | UV SPECTROPHOTOMETRY METHOD FOR THE ESTIMATION OF DEXLANSOPRAZOLE IN BULK AND PHARMACEUTICAL FORMULATIONS |
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Sonja Jose |
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The main objective was to develop and validate the UV spectrophotometric method for the estimation of
Dexlansoprazole in bulk and its tablet dosage formulations as per ICH guidelines. Distilled water is used as asolvent. The ? max
of the dexlansoprazole was found to be 284 nm. The linearity in the concentration range 5-30 µg/mlwith co relation co
efficient of 0.9996. The accuracy studies of proposed method was performed at three different levels, 20%, 40%, 60% and
recovery was found to be in the range of 100.82%. The limit of detection and limit of quantification were found to be 0.0383
and 0.1160 µg/ml respectively. The %RSD less than 2 which indicates the accuracy and precise of the method the above
method was a rapid tool for routine analysis of Dexlansoprazole in the bulk and its tablet dosage forms
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2. | METHOD DEVELOPMENT OF DETERMINATION OF QUALITY AND QUANTITY IN POLY-HERBAL DOSAGE FORM OF CARYOPHYLLINE |
| Shiva Kumar Tejavath*, R. Shankar Sheshu, S. Selva Kumar, Srikanth A, M.Purushothaman |
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Caryophyllene otherwise called as (-)-β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of Cannabis sativa, rosemary, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer. Caryophyllene is notable for having a cyclobutane ring, as well as a trans-double bond in a 9-membered ring, both rarities in nature. It has ability to bind with CB2 receptors in the endocannabinoidsystem, beta-caryophyllene has potent anti-inflammatory and antioxidant effects. It could help to relieve pain and anxiety, treat seizures, and reduce cholesterol. The conclusion shows the proposed method is simple, accurate, rapid, precise, economic and reproducible for UV spectrophotometric of caryophyllene estimation from pharmaceutical formulation. This method is applied for routine estimation of caryophylline in bulk & pharmaceutical dosage form
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3. | FORMULATION AND EVALUATION OF CEFUROXIME AXETIL
ORAL SUSPENSION |
| Balasubramanian V, Senthil Kumar K L, Vijaya K |
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Cefuroxime is the second-generation cephalosporin, which its intravenous and oral dosage forms are available. Oral route is
the selective method for administration of most of the drugs. The aim of this study was formulating ‘for oral’ cefuroxime
axetil suspensions. From all formulations, were selected to further investigation. Considering no sedimentation, the
sedimentation volume was determined. All selected formulations released which was acceptable. The results of assay test
also proved that all formulations contain the drug in acceptable. The viscosity curves showed that the systems were pseudo
plastic and thixotrop. Designed cefuroxime axetil formulations had good qualities and could be added as a new product to
drug marketing
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